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KMID : 0376619920170010001
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Seoul Journal of Psychiatry
1992 Volume.17 No. 1 p.1 ~ p.8
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The Abnormalities of Immune Function in Schizophrenics(III)
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Abstract
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In Present study, we investigated to determine a potentially irreversible or residual effects of prior neuroleptic drug therapy on immune functions and the abnormalities of immune functions in schizophrenic patients.
All patients(n=14) met DSM-III-R criteria for schizophrenia, who were hospitalized at the closed ward of Paik Hospital, Seoul. Seven patients were newly diagnosed schizophrenia who never received any antipsychotic therapy. Of remaining patients,
seven
were psychotic relapsed patients following discontinuation of neuroleptic drug therapy. The 14 controls were recruited from healthy university students. And we compared the 14 patients who were before treatment and who were after 4-6 weeks of
follow up
with antipsycotic therapy(average equivalent to 25mg of haloperidol) in these patients. The immune cells were determined by moncoclonal antibody techniques.
The results were as following. First, there were no significant differences in immune cells at admission between a group of newly diagnosed schizophrenic patients who had never received neuroleptic therapy and a group of relapsed schizophrenic
patients
following discontinuation of antipsychotic therapy. Second, the numbers of lymphocytes(p<.01), t-cells(p<.05), B-cells(p0.5) were siginificantly more but the percentage of Tcells(p,0.5) were significantly less in acutely ill, unmedicated,
schizophrenic
patients(n=14) than controls. third, there were more decreases in the percentages of lymphocytes(p<.01), T-cells(p.01)and in the numbers of lymphocytes(p<.01), T-cells(P<.01), B-cells(p<.05) after the administrating of neuroleptic drug therapy
for
4-6
weeks than before the beginning of neuroleptic drug therapy. Fourth, the percentages of T-cells(p<.01), CD4+ T-cell(p<.05), CD8+T-cell(p<.01) and the number of T-cells(p<.01) were significantly less in acutely ill, medicated, schizophrenic
patients(n=14) than controls.
The results suggests that depressive effect of neuroleptics on immune function was not irreversible and some immune dysfunction may exist in acutely ill schizophrenia. Further study were required to determine the relevance of immune abnormality
to
the
etiology of schizophrenia.
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KEYWORD
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